We would like to thank everyone for participating in and supporting Lemonade for Livy! The excitement leading up to the weekend and the turning of the last handful of states purple was amazing. There was incredible energy throughout the country during Lemonade for Livy as we came together to spread epilepsy awareness and raise money for research.
The voting for this year’s most creative stand has concluded and here are the winners:
First Place - Paul & Lily from Arizona Second Place - Connor from Rhode Island
Third Place - Mallory from Illinois Honorable Mention - Murphy from New York
We are also incredibly excited to announce that Lemonade for Livy, to date, has raised $15,300 with several more stands to submit their funds! We have worked with the Epilepsy Foundation of America to select a research project to fund. This is an amazing accomplishment for the first year as a national campaign. Congratulations to everyone who either held or visited a stand or helped along the way. This is how we make a difference and find a cure!
The description of the research project is below.
This year was just the beginning. Lemonade for Livy is a movement inspired by every person and family who participates. Our goal is to spread it around the globe. Epilepsy affects 65 million people and it will take a continuous international effort to find a cure. We have already set the date for Lemonade for Livy Weekend 2015 to be July 24th – 26th. How many countries do you think we can get involved? It should be a lot of fun to find out. Keep watching for news and announcements as we go.
And don’t forget, you can have a stand or party anytime throughout the year. It is also a great idea to have a Lemonade for Livy stand at walks, runs or other events. We would love to work with you and help in any way we can.
Our family is dedicated to finding a cure for epilepsy. Livy has been our inspiration. But after reading the stories we received during the campaign about the families who struggle with epilepsy on a daily basis, we are even more determined to bring people together from across the globe to find a cure. Please continue to spread Lemonade for Livy and give people the hope they deserve. When you support Lemonade for Livy, you are making a stand against epilepsy. Remember, if we work as one, if we speak with a unified voice, we can make significant progress toward finding a cure.
Jon, Allison, Hailey and Livy
Chun-Hay Alex Kwan, PhD
Yale University School of Medicine
Project Name: The spatiotemporal dynamics of GABAergic neuronal activity in epilepsy
Abstract: It is widely accepted that the onset and propagation of seizure activity in epilepsy depends critically on the dynamics between excitation and inhibition in the brain. Recruited by synchronized activity, inhibitory neurons restrain and define the spatial extent of the epileptiform discharges in the neocortex. However, there are several major types of inhibitory neurons, each with distinct electrical properties and physiological functions. It remains unclear how these different types of inhibitory neurons are recruited and restraining excitation during epileptiform activity in vivo. This lack of understanding hampers the development of targeted treatments for epilepsy. This proposal will directly address this significant gap in the knowledge of epilepsy by using cutting-edge optical technologies, including two-photon calcium imaging and optogenetics, which enable in vivo recording and manipulation of neural activity. In a mouse model of epilepsy, the experiments will visualize the dynamics of inhibitory activity and then causally test whether elevating inhibition can terminate seizures. The goal is to identify the inhibitory neuronal circuits in the cortex that are responsible for restraining hyperexcitation during seizures.